Kitai Ryuhei, Matsuda Ken, Adachi Erika, Saito Yasushi, Nakajima Tsuyoshi, Takeuchi Hiroaki, Sato Kazufumi, Imamura Yoshiaki, Kubota Toshihiko
Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui.
Neurol Med Chir (Tokyo). 2010;50(2):114-8. doi: 10.2176/nmc.50.114.
The incidence of Epstein-Barr virus (EBV)-associated primary central nervous system (CNS) lymphoma in Japan was assessed using in situ hybridization of EBV-encoded small ribonucleic acid-1 (EBER-1) to identify the presence of EBV in 22 cases of formalin-fixed and paraffin-embedded primary CNS lymphoma. All cases were B-cell lymphoma. EBER-1 expression was observed in the nuclei of 3 of 22 primary CNS lymphoma cases (13.6%). The incidence of EBV-positive lymphoma in Japanese cases is higher than previously reported from Western countries. Patients with EBV-positive primary CNS lymphoma showed shorter survival than those with negative tumors (median 4 months vs. 26 months). EBER-1 in situ hybridization for the detection of EBV infection is rapid and reliable. Infrequent association suggests a different pathogenetic mechanism in the evolution of these tumors. Geographical differences in the incidence of EBV-associated primary CNS lymphoma may reflect epidemiological factors.
利用爱泼斯坦-巴尔病毒（EBV）编码的小核糖核酸-1（EBER-1）原位杂交技术，对22例福尔马林固定、石蜡包埋的原发性中枢神经系统（CNS）淋巴瘤病例进行检测，以确定EBV的存在，从而评估日本EBV相关原发性中枢神经系统淋巴瘤的发病率。所有病例均为B细胞淋巴瘤。在22例原发性中枢神经系统淋巴瘤病例中，有3例（13.6%）的细胞核中观察到EBER-1表达。日本病例中EBV阳性淋巴瘤的发病率高于西方国家先前报道的发病率。EBV阳性原发性中枢神经系统淋巴瘤患者的生存期短于EBV阴性肿瘤患者（中位生存期分别为4个月和26个月）。用于检测EBV感染的EBER-1原位杂交快速且可靠。EBV与原发性中枢神经系统淋巴瘤的关联较少，提示这些肿瘤在发生发展过程中有不同的致病机制。EBV相关原发性中枢神经系统淋巴瘤发病率的地理差异可能反映了流行病学因素。
