Gala Roshani, Gandhi Jatin S, Gupta Gurudutt, Grover Shrruti K, Sharma Anila, Pasricha Sunil, Mehta Anurag
Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Indian J Pathol Microbiol. 2017 Jul-Sep;60(3):341-349. doi: 10.4103/IJPM.IJPM_49_17.
The Epstein-Barr virus (EBV), also called human herpesvirus 4, is a virus of the herpes family. The EBV-associated lymphomas include Burkitt lymphoma, classic Hodgkin lymphoma (HL), lymphomas arising in immunocompromised individuals, peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphoma, extranodal nasal-type natural killer/T-cell lymphoma, and other rare histotypes.
The present study evaluated the role of EBV as an etiologic agent in various lymphomas and determined an Indian perspective in a tertiary care cancer center compared to that of Western literature.
Clinicopathological spectrum was studied in 184 cases of lymphomas using a standard immunohistochemistry panel and in situ hybridization for Epstein-Barr virus-encoded RNA (EBER) expression.
The prevalence of EBV was described in various HL and non-HL's and was found similar to that of Western literature. EBER expression was also observed in the nonneoplastic bystander cells in the studied cases which need further evaluation on larger scale studies.
爱泼斯坦-巴尔病毒（EBV），也称为人类疱疹病毒4型，是一种疱疹家族病毒。与EBV相关的淋巴瘤包括伯基特淋巴瘤、经典霍奇金淋巴瘤（HL）、免疫功能低下个体发生的淋巴瘤、外周T细胞淋巴瘤、血管免疫母细胞性T细胞淋巴瘤、结外鼻型自然杀伤/T细胞淋巴瘤以及其他罕见组织学类型。
本研究评估了EBV作为各种淋巴瘤病因的作用，并与西方文献相比，确定了一家三级医疗癌症中心的印度视角。
使用标准免疫组织化学检测板和原位杂交技术检测爱泼斯坦-巴尔病毒编码RNA（EBER）表达，对184例淋巴瘤病例的临床病理谱进行研究。
描述了EBV在各种HL和非HL中的患病率，发现与西方文献相似。在所研究的病例中，非肿瘤旁细胞中也观察到EBER表达，这需要在更大规模的研究中进一步评估。
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