Lafayette Thereza Christina Sampaio, Coser Virginia Maria, Brûlé Alice Odette, Coser Pedro Luis, Pereira Waldir Veiga
Department of Pediatric Hematology-Oncology, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
J Pediatr Hematol Oncol. 2010 Apr;32(3):229-32. doi: 10.1097/MPH.0b013e3181cf7ef3.
Extramedullary involvement occurs infrequently in acute promyelocytic leukemia and is said to be more common after treatment with all-trans retinoic acid. We describe a 9-year-old girl who had an isolated external auditory canal and middle ear relapse after treatment with all-trans retinoic acid and chemotherapy. A patient with cytogenetically and molecularly confirmed acute promyelocytic leukemia developed isolated extramedullary relapse in the auditory canal and middle ear 4 years and 9 months after initial diagnosis, while in hematologic and molecular remission, successfully treated with arsenic trioxide alone.
髓外浸润在急性早幼粒细胞白血病中很少见，据说在全反式维甲酸治疗后更为常见。我们描述了一名9岁女孩，她在接受全反式维甲酸和化疗后出现了孤立的外耳道和中耳复发。一名经细胞遗传学和分子学确诊的急性早幼粒细胞白血病患者在初次诊断后4年9个月出现了孤立的外耳道和中耳髓外复发，当时处于血液学和分子学缓解状态，仅用三氧化二砷成功治疗。
