Philippens Ingrid H C H M, Vanwersch Raymond A P
Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Neuroreport. 2010 Mar 31;21(5):328-32. doi: 10.1097/WNR.0b013e3283360ba8.
Neurofeedback research in a model closely related to humans is recommended to rule out placebo effects and unspecific factors bridging the gap between nonvalidated empirical and standardized controlled research. In this article, telemetric sensorimotor rhythm (SMR; 11-14 Hz) feedback training in the marmoset monkey is applied to examine the monkey's capability to voluntary control their brain activity. Four monkeys, provided with two epidural bioelectric electrodes above the sensorimotor cortex, were trained with positive reinforcement on SMR measured by online analyses of 1.28 s electroencephalogram epochs in 30-min sessions. These monkeys learned within five sessions to increase their alpha activity. The first evidence of nonhuman primates having an operant control over the SMR is provided, an initial step for a much-needed scientific basis to neurofeedback.
建议在与人类密切相关的模型中进行神经反馈研究，以排除安慰剂效应和弥合未经验证的实证研究与标准化对照研究之间差距的非特异性因素。在本文中，对狨猴进行遥测感觉运动节律（SMR；11 - 14赫兹）反馈训练，以检验猴子自主控制其大脑活动的能力。给四只在感觉运动皮层上方植入两个硬膜外生物电电极的猴子，通过对1.28秒脑电图片段进行在线分析来测量SMR，并在30分钟的训练时段内给予正强化训练。这些猴子在五个训练时段内学会了增加它们的阿尔法活动。本文提供了非人类灵长类动物对SMR进行操作性控制的首个证据，这是为神经反馈建立急需的科学基础的第一步。
