Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
J Antibiot (Tokyo). 2010 Apr;63(4):183-6. doi: 10.1038/ja.2010.14. Epub 2010 Feb 26.
Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 microg ml(-1), respectively.
钙泊三醇，一种新的抗分枝杆菌药物，从真菌菌株蜡蚧轮枝菌 FKI-4905 的发酵液中通过溶剂萃取、十八烷基硅烷柱色谱和制备高效液相色谱分离得到。钙泊三醇仅对分枝杆菌属中的各种微生物，包括革兰氏阳性和革兰氏阴性细菌、真菌和酵母具有活性。钙泊三醇对耻垢分枝杆菌和结核分枝杆菌的生长均具有抑制作用，MIC 值分别为 0.78 和 12.5μg/ml。
