帕金森病中 parkin 基因的作用：家族性与散发性帕金森病。
The role of parkin in familial and sporadic Parkinson's disease.
机构信息
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
Mov Disord. 2010;25 Suppl 1(0 1):S32-9. doi: 10.1002/mds.22798.
Abstract
Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD.
摘要
Parkin 基因突变是仅次于帕金森病（PD）的第二大常见原因。Parkin 是一种泛素 E3 连接酶，可单泛素化和多泛素化蛋白质，以调节多种细胞过程。Parkin 的 E3 连接酶活性丧失被认为在遗传性和散发性 PD 中都起着致病作用。在这里，我们回顾了 Parkin 的生物学和病理生物学及其在 PD 发病机制中的作用。
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Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels.帕金介导的PDZ蛋白PICK1单泛素化调节酸敏感离子通道的活性。
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