MRC Clinical Sciences Centre and Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK.
Mov Disord. 2010;25 Suppl 1:S83-8. doi: 10.1002/mds.22720.
In this review, in vivo patterns of structural, metabolic, and neurotransmitter binding changes revealed by imaging in both symptomatic Parkinson's disease (PD) and at-risk subjects are compared with those predicted at different Braak stages. It is concluded that the dysfunction revealed by imaging in PD is only partially in line with the sequential ascending topography of Lewy body pathology reported by Braak, suggesting that neurons in different brain regions are likely to be selectively vulnerable to the presence of intracellular synuclein aggregates.
在这篇综述中，对比了在有症状的帕金森病 (PD) 患者和高危人群中通过成像观察到的结构、代谢和神经递质结合变化的体内模式与不同 Braak 阶段预测的模式。结论是，PD 中成像显示的功能障碍与 Braak 报告的路易体病理的顺序上升拓扑结构仅部分一致，这表明不同脑区的神经元可能容易受到细胞内突触核蛋白聚集物的影响。
