The George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, California 90033, USA.
Mov Disord. 2010;25 Suppl 1(0 1):S141-5. doi: 10.1002/mds.22782.
Epidemiological and clinical trials have suggested that exercise is beneficial for patients with Parkinson's disease (PD). However, the underlying mechanisms and potential for disease modification are currently unknown. This review presents current findings from our laboratories in patients with PD and animal models. The data indicate that alterations in both dopaminergic and glutamatergic neurotransmission, induced by activity-dependent (exercise) processes, may mitigate the cortically driven hyper-excitability in the basal ganglia normally observed in the parkinsonian state. These insights have potential to identify novel therapeutic treatments capable of reversing or delaying disease progression in PD.
流行病学和临床试验表明，运动对帕金森病（PD）患者有益。然而，其潜在的机制和疾病改善的潜力目前尚不清楚。本综述介绍了我们实验室在 PD 患者和动物模型中的最新发现。这些数据表明，活动依赖性（运动）过程引起的多巴胺能和谷氨酸能神经传递的改变，可能减轻帕金森状态下基底神经节中通常观察到的皮质驱动的过度兴奋。这些研究结果有可能确定新的治疗方法，以逆转或延缓 PD 的疾病进展。
