Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, Toronto, Ontario, Canada.
Mov Disord. 2010;25 Suppl 1:S71-5. doi: 10.1002/mds.22714.
Despite improvements in anatomic imaging of the basal ganglia, microelectrode recording is still an invaluable tool in locating appropriate targets for neurosurgical intervention. These recording also provide an unparalleled opportunity to study the pathophysiological aspects of diseases. This article reviews the principles of microelectrode recording in functional neurosurgery and discusses the pathologic neurophysiologic findings commonly encountered. It also highlights some of the potential mechanisms of action of both dopaminergic drugs and deep brain stimulation. In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease.
尽管基底神经节的解剖成像有了改进，但微电极记录仍然是确定神经外科干预的适当目标的宝贵工具。这些记录还提供了无与伦比的机会来研究疾病的病理生理方面。本文回顾了功能神经外科中微电极记录的原理，并讨论了常见的病理神经生理发现。它还强调了一些多巴胺能药物和深部脑刺激的潜在作用机制。此外，我们还回顾了关于动眼神经核团神经生理学的最新工作以及在帕金森病步态障碍中该区域深部脑刺激的试验。
