Department of Neurology, University of Iowa, Iowa City, IA, United States.
Department of Neurology, University of Iowa, Iowa City, IA, United States.
Prog Brain Res. 2022;269(1):435-455. doi: 10.1016/bs.pbr.2022.01.016. Epub 2022 Feb 11.
Neuromodulation is a widely used treatment for motor symptoms of Parkinson's disease (PD). It can be a highly effective treatment as a result of knowledge of circuit dysfunction associated with motor symptoms in PD. However, the mechanisms underlying cognitive symptoms of PD are less well-known, and the effects of neuromodulation on these symptoms are less consistent. Nonetheless, neuromodulation provides a unique opportunity to modulate motor and cognitive circuits while minimizing off-target side effects. We review the modalities of neuromodulation used in PD and the potential implications for cognitive symptoms. There have been some encouraging findings with both invasive and noninvasive modalities of neuromodulation, and there are promising advances being made in the field of therapeutic neuromodulation. Substantial work is needed to determine which modulation targets are most effective for the different types of cognitive deficits of PD.
神经调节是治疗帕金森病（PD）运动症状的常用方法。由于了解了与 PD 运动症状相关的回路功能障碍，它可以成为一种非常有效的治疗方法。然而，PD 认知症状的机制还不太清楚，神经调节对这些症状的效果也不一致。尽管如此，神经调节提供了一个独特的机会，可以在最小化脱靶副作用的同时调节运动和认知回路。我们回顾了 PD 中使用的神经调节方式以及对认知症状的潜在影响。神经调节的有创和无创方式都有一些令人鼓舞的发现，治疗性神经调节领域也取得了有前途的进展。需要做大量的工作来确定哪种调节靶点对 PD 的不同类型的认知缺陷最有效。
