评估儿童肝细胞损伤的抗氧化状态和脂质过氧化活性。

Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children.

机构信息

Department of Medical Biochemistry, Medical Research Division, National Research Centre, Cairo, Egypt.

出版信息

East Mediterr Health J. 2009 Jul-Aug;15(4):842-52.

PMID:20187535

Abstract

Serum levels of glutathione reductase (GR), glutathione S-transferase-alpha (GST-alpha) and malondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. Except for level of GR in patients with HBV, GR, GST-alpha and MDA were raised significantly in patients compared with controls. At 100% specificity, the sensitivity of the 3 markers for detecting hepatitis B virus, hepatitis C virus and schistosomiasis infection respectively were: 16.7%, 100.0% and 17.7% for GR; 33.3%, 62.1% and 38.2% for GST-alpha; and 25.0%, 10.3% and 29.4% for MDA. GR was more sensitive in hepatitis C infection, while MDA reflected changes in liver ultrasound and GST-alpha was the best indicator for histopathological changes.

摘要

检测了 75 例肝病患儿血清谷胱甘肽还原酶（GR）、谷胱甘肽 S-转移酶-α（GST-α）和丙二醛（MDA）的水平，以评估它们在诊断肝细胞损伤中的作用。除了乙型肝炎病毒患者的 GR 水平外，与对照组相比，患者的 GR、GST-α 和 MDA 水平均显著升高。在特异性为 100%时，这 3 种标志物检测乙型肝炎病毒、丙型肝炎病毒和血吸虫病感染的灵敏度分别为：GR 为 16.7%、100.0%和 17.7%；GST-α为 33.3%、62.1%和 38.2%；MDA 为 25.0%、10.3%和 29.4%。GR 在丙型肝炎感染中更敏感，而 MDA 反映了肝脏超声的变化，GST-α是组织病理学变化的最佳指标。