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伊朗东南部患者常见的乙型肝炎病毒基因型。

Common HBV genotype in southeastern Iranian patients.

机构信息

Department of Microbiology, Hematology, and Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

出版信息

Arch Iran Med. 2010 Mar;13(2):147-9.

Abstract

Asymptomatic hepatitis B infection is characterized as a type of hepatitis in which hepatitis B surface antigen is present in the patient's peripheral blood despite the absence of clinical symptoms. Previous studies have shown that a particular genotype may effect clinical manifestations of hepatitis B infection; hence, the aim of the current study was to determine the frequency of hepatitis B virus genotypes among asymptomatic carriers of hepatitis B.In this experimental study, the plasma samples of 100 asymptomatic carriers were collected and tested for HBsAg and anti-HBs using ELISA. The genotype of hepatitis B virus was determined by the GAP-PCR technique. The results of this study showed that all samples were positive for hepatitis B surface antigen and anti-hepatitis B core antigen was present in 60 (60%) cases. Our results also indicated that all patients had the D genotype of hepatitis B virus.

摘要

无症状乙型肝炎感染的特征是一种乙型肝炎,尽管患者没有临床症状,但乙型肝炎表面抗原存在于其外周血液中。先前的研究表明,特定的基因型可能会影响乙型肝炎感染的临床表现;因此,本研究的目的是确定无症状乙型肝炎携带者中乙型肝炎病毒基因型的频率。在这项实验研究中,收集了 100 例无症状携带者的血浆样本,并使用 ELISA 检测 HBsAg 和抗-HBs。乙型肝炎病毒的基因型通过 GAP-PCR 技术确定。本研究结果表明,所有样本均为乙型肝炎表面抗原阳性,抗乙型肝炎核心抗原阳性 60 例(60%)。我们的结果还表明,所有患者均具有乙型肝炎病毒 D 基因型。

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