白细胞介素-10启动子基因多态性对慢性乙型肝炎感染严重程度的影响。
Impact of the IL-10 Promoter Gene Polymorphisms in the Severity of Chronic Hepatitis B Infection.
作者信息
Ghaleh Baghi Sahand, Alavian Seyed Moayed, Mehrnoush Leila, Salimi Shima
机构信息
Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Tehran, IR Iran ; Department of Otolaryngology and Head and Neck Surgery, Rasool Akram Hospital, Tehran, IR Iran.
Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Tehran, IR Iran ; Middle East Liver Disease Center (MELD), Tehran, IR Iran.
出版信息
Hepat Mon. 2015 Jul 22;15(7):e28287. doi: 10.5812/hepatmon.28287v2. eCollection 2015 Jul.
BACKGROUND
Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection.
OBJECTIVES
The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in patients with chronic hepatitis B.
PATIENTS AND METHODS
Totally, 166 patients with chronic hepatitis B infection were enrolled. Genotypes at different positions (i.e. -819, - 592, and - 1082) in the IL-10 gene promoter were determined.
RESULTS
The C/A genotype at position -592, C/T genotype at position -819, and GCC/ATA haplotype of the IL-10 gene promoter were significantly more common in the patients with cirrhosis. The genotypes were significantly different between the hepatitis B e antigen (HBeAg)-negative and HBeAg-positive patients at position -592 (C/A and C/C), position -819 (C/C and C/T), and position -1082 (A/A and G/A).
CONCLUSIONS
Some IL-10 promoter gene polymorphisms predisposed the infected hepatitis B virus cases to cirrhosis in our study population.
背景
白细胞介素-10（IL-10）是一种重要的抗炎细胞因子。其启动子基因多态性被认为与乙型肝炎感染的慢性化有关。
目的
本研究旨在评估慢性乙型肝炎患者IL-10启动子基因不同位置的多态性。
患者与方法
共纳入166例慢性乙型肝炎感染患者。测定IL-10基因启动子不同位置（即-819、-592和-1082）的基因型。
结果
-592位点的C/A基因型、-819位点的C/T基因型以及IL-10基因启动子的GCC/ATA单倍型在肝硬化患者中显著更为常见。在-592位点（C/A和C/C）、-819位点（C/C和C/T）以及-1082位点（A/A和G/A），乙型肝炎e抗原（HBeAg）阴性和HBeAg阳性患者的基因型存在显著差异。
结论
在我们的研究人群中，某些IL-10启动子基因多态性使感染乙型肝炎病毒的病例易患肝硬化。
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