扎伊德氏肝癌的线粒体腺苷三磷酸酶。III. 解偶联剂对线粒体内ATP水解的影响。
Mitochondrial adenosine triphosphatase of Zajdela hepatoma. III. Effect of uncouplers on the hydrolysis of intramitochondrial ATP.
作者信息
Kolarov J, Kuzela S, Krempaský V, Ujházy V
出版信息
Neoplasma. 1977;24(6):649-51.
PMID:201877
Abstract
Hydrolysis of extramitochondrial ATP by coupled Zajdela hepatoma mitochondria is not stimulated by uncouplers of oxidative phosphorylation. The results of the present study show that the hydrolysis of intramitochondrial ATP in these mitochondria is stimulated by DNP and CCCP. It is proposed that the uncoupler insensitivity of ATPase in coupled Zajdela hepatoma mitochondria with exogenous ATP as a substrate result from an altered functional relationship between ATPase and ADP, ATP translocase.
摘要
偶联的扎伊德氏肝癌线粒体对胞外线粒体ATP的水解作用不受氧化磷酸化解偶联剂的刺激。本研究结果表明，这些线粒体中线粒体内ATP的水解受到二硝基苯酚（DNP）和羰基氰-间-氯苯腙（CCCP）的刺激。有人提出，以外源ATP为底物的偶联扎伊德氏肝癌线粒体中ATP酶对解偶联剂不敏感，是由于ATP酶与ADP、ATP转位酶之间的功能关系发生了改变。
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