饮食模式与食管鳞癌风险：病例对照研究。
Dietary patterns and risk of oesophageal squamous cell carcinoma: a case-control study.
机构信息
Department of Radiation Oncology, Kurdistan University of Medical Sciences, Iran.
出版信息
Public Health Nutr. 2010 Jul;13(7):1107-12. doi: 10.1017/S1368980010000145. Epub 2010 Mar 1.
OBJECTIVE
We conducted a hospital-based, case-control study to examine the association between dietary patterns and the risk of oesophageal squamous cell carcinoma in Iran.
DESIGN
A total of forty-seven patients with oesophageal squamous cell carcinoma and ninety-six controls underwent face-to-face interviews. Factor analysis was used to detect dietary patterns. Multivariate logistic regression was used to estimate OR and 95% CI.
RESULTS
We defined two major dietary patterns in this population: 'healthy diet' (high in vegetables, nuts, fruits, low-fat dairy and fish) and 'western diet' (high in solid oil, sugar, sweets, tea, eggs, pickles and processed meat). Both healthy and western pattern scores were divided into two categories (based on medians). Higher healthy pattern scores were significantly associated with decreased risk of oesophageal squamous cell carcinoma (high: second median v. low: first median, OR = 0.17, 95% CI 0.19, 0.98). An increased risk of oesophageal squamous cell carcinoma was observed with the western pattern (high: second median v. low: first median, OR = 10.13, 95% CI 8.45, 43.68).
CONCLUSIONS
The results of the present study suggested that diet might be associated with oesophageal carcinoma.
目的
我们进行了一项基于医院的病例对照研究，以检验伊朗饮食模式与食管鳞状细胞癌风险之间的关联。
设计
共有 47 名食管鳞状细胞癌患者和 96 名对照接受了面对面访谈。采用因子分析来检测饮食模式。采用多变量逻辑回归来估计 OR 和 95%CI。
结果
我们在该人群中定义了两种主要的饮食模式：“健康饮食”（富含蔬菜、坚果、水果、低脂乳制品和鱼类）和“西方饮食”（富含固体油、糖、甜食、茶、鸡蛋、泡菜和加工肉类）。健康模式和西方模式得分均分为两类（基于中位数）。较高的健康模式得分与食管鳞状细胞癌风险降低显著相关（高：第二中位数 v. 低：第一中位数，OR=0.17，95%CI 0.19，0.98）。西方模式与食管鳞状细胞癌风险增加相关（高：第二中位数 v. 低：第一中位数，OR=10.13，95%CI 8.45，43.68）。
结论
本研究结果表明，饮食可能与食管癌有关。
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