调节性T细胞，靶向免疫疗法的进展。

T regulatory cells, the evolution of targeted immunotherapy.

作者信息

Nizar S, Meyer B, Galustian C, Kumar D, Dalgleish A

机构信息

Department of Cellular and Molecular Medicine, St George's University of London, UK.

出版信息

Biochim Biophys Acta. 2010 Aug;1806(1):7-17. doi: 10.1016/j.bbcan.2010.02.001. Epub 2010 Feb 23.

DOI:10.1016/j.bbcan.2010.02.001

PMID:20188145

Abstract

T regulatory cells are able to suppress anti-tumour immunity in pre-clinical models and in patients. This review highlights the important discoveries in Treg immunology critical to the evolution of targeted immunotherapy. We also describe the therapeutic applications that are currently being assessed and their future potential.

摘要

调节性T细胞能够在临床前模型和患者体内抑制抗肿瘤免疫。本综述重点介绍了对靶向免疫治疗发展至关重要的调节性T细胞免疫学的重要发现。我们还描述了目前正在评估的治疗应用及其未来潜力。