Grillon C, Ameli R, Glazer W M
Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06510-3223.
Biol Psychiatry. 1991 Mar 1;29(5):467-80. doi: 10.1016/0006-3223(91)90269-r.
The N400 component of event-related potentials (ERPs) was investigated in medicated schizophrenic patients and normal controls in a semantic categorization task. The subjects' task was to indicate whether pairs of words were semantically related or unrelated. The ERPs to the unrelated second words of the pairs contained a negative component, N400, which was reduced and delayed in the patients. However, inspection of individual subjects' data indicated that N400 was abnormal only in a subgroup of schizophrenics. Abnormalities in the amplitude of N400 suggest impairments in semantic expectancies, whereas abnormalities in the latency of N400 suggest a delay in information processing.
在一项语义分类任务中，对服用药物的精神分裂症患者和正常对照组进行了事件相关电位（ERP）的N400成分研究。受试者的任务是指出单词对在语义上是相关还是不相关。对单词对中不相关的第二个单词的ERP包含一个负成分N400，该成分在患者中降低且延迟。然而，对个体受试者数据的检查表明，N400仅在一部分精神分裂症患者中异常。N400振幅异常表明语义预期受损，而N400潜伏期异常表明信息处理延迟。
