Department of Psychology, Tufts University, Medford, MA 02155, USA.
Int J Psychophysiol. 2010 Feb;75(2):66-76. doi: 10.1016/j.ijpsycho.2009.09.005. Epub 2009 Sep 15.
Disturbances of thought and language are fundamental to schizophrenia. Cognitive behavioral and electrophysiological research has implicated problems in two different neurocognitive mechanisms: abnormalities in the structure and function of semantic memory, and abnormalities in combining and integrating words together to build up sentence and discourse context. This review discusses recent electrophysiological evidence suggesting that these two deficits are not completely distinct, but rather that language impairment in schizophrenia results from a dysfunctional interaction between these systems in an effort to build up higher-order meaning. Moreover, although language abnormalities are more pronounced in patients with positive thought disorder, they manifest themselves in all patients when increased demands are placed on the comprehension system. Further investigation of language dysfunction may also provide insights into other aspects of psychotic thought.
思维和语言障碍是精神分裂症的基础。认知行为和电生理研究表明，两个不同的神经认知机制存在问题：语义记忆的结构和功能异常，以及将单词组合和整合在一起构建句子和语篇语境的异常。这篇综述讨论了最近的电生理证据，表明这两种缺陷并非完全不同，而是精神分裂症的语言障碍是由于这些系统之间的功能障碍相互作用，试图构建更高层次的意义。此外，尽管阳性思维障碍患者的语言异常更为明显，但当理解系统的要求增加时，所有患者都会表现出这种异常。进一步研究语言功能障碍也可能为精神思维的其他方面提供深入的了解。
