尼古丁阻断大脑雌激素合酶（芳香酶）：雌性狒狒体内的正电子发射断层扫描研究。
Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons.
机构信息
Brookhaven National Laboratory, Upton, New York, USA.
出版信息
Biol Psychiatry. 2010 Apr 15;67(8):774-7. doi: 10.1016/j.biopsych.2010.01.004. Epub 2010 Feb 25.
Abstract
BACKGROUND
Cigarette smoking and nicotine have complex effects on human physiology and behavior, including some effects similar to those elicited by inhibition of aromatase, the last enzyme in estrogen biosynthesis. We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase.
METHODS
Brain aromatase availability was examined with positron emission tomography and the selective aromatase inhibitor [(11)C]vorozole in six baboons before and after exposure to IV nicotine at .015 and .03 mg/kg.
RESULTS
Nicotine administration produced significant, dose-dependent reductions in [(11)C]vorozole binding. The amygdala and preoptic area showed the largest reductions. Plasma levels of nicotine and its major metabolite cotinine were similar to those found in cigarette smokers.
CONCLUSIONS
Nicotine interacts in vivo with primate brain aromatase in regions involved in mood, aggression, and sexual behavior.
摘要
背景
吸烟和尼古丁对人体生理和行为有复杂的影响，包括一些类似于芳香化酶抑制的作用，芳香化酶是雌激素生物合成的最后一种酶。我们报告了第一个体内灵长类动物研究，以确定尼古丁给药是否对大脑芳香化酶有直接影响。
方法
在 6 只狨猴中，使用正电子发射断层扫描和选择性芳香化酶抑制剂[(11)C]vorozole，在静脉注射尼古丁 0.015 和 0.03mg/kg 前后，检查脑内芳香化酶的可用性。
结果
尼古丁给药产生了显著的、剂量依赖性的[(11)C]vorozole 结合减少。杏仁核和视前区的减少最大。尼古丁和其主要代谢物可替宁的血浆水平与吸烟者相似。
结论
尼古丁在体内与灵长类动物大脑中的芳香化酶相互作用，涉及情绪、攻击和性行为等区域。
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