Division of Reproductive Endocrinology and Infertility, Washington University School of Medicine, St. Louis, Missouri, USA.
Fertil Steril. 2011 May;95(6):1890-7. doi: 10.1016/j.fertnstert.2010.01.016. Epub 2010 Feb 26.
To articulate the need for a new approach to primary ovarian insufficiency. The condition, also known as premature menopause or premature ovarian failure, is defined by the presence of menopausal-level serum gonadotropins in association with irregular menses in adolescent girls or women younger than 40 years. It can be iatrogenic as related to cancer therapy or may arise spontaneously, either alone or as part of a host of ultrarare syndromes. In a large percentage of spontaneous cases no pathogenic mechanism can be identified.
Literature review and consensus building at a multidisciplinary scientific workshop.
CONCLUSION(S): There are major gaps in knowledge regarding the etiologic mechanisms, psychosocial effects, natural history, and medical and psychosocial management of primary ovarian insufficiency. An international research consortium and disease registry formed under the guidance of an umbrella organization would provide a pathway to comprehensively increase basic and clinical knowledge about the condition. Such a consortium and patient registry also would provide clinical samples and clinical data with a goal toward defining the specific pathogenic mechanisms. An international collaborative approach that combines the structure of a patient registry with the principles of integrative care and community-based participatory research is needed to advance the field of primary ovarian insufficiency.
阐述原发性卵巢功能不全需要新的治疗方法。该疾病又称为早发性卵巢功能不全或卵巢早衰，其定义为青春期女孩或 40 岁以下的女性血清促性腺激素达到绝经水平，同时伴有月经不规则。该疾病可能由癌症治疗引起，也可能是自发性的，可单独发生，也可能是许多超罕见综合征的一部分。在很大一部分自发性病例中，无法确定发病机制。
文献回顾和多学科科学研讨会的共识制定。
原发性卵巢功能不全的病因机制、心理社会影响、自然病史以及医学和心理社会管理方面的知识仍存在重大空白。在一个伞式组织的指导下，成立一个国际性研究联盟和疾病登记处，将为全面增加对该疾病的基础和临床知识提供途径。这样的联盟和患者登记处还将提供临床样本和临床数据，旨在确定特定的发病机制。需要一种结合患者登记处结构、综合护理和基于社区的参与性研究原则的国际合作方法，以推进原发性卵巢功能不全领域的发展。
