一种新的非侵入性技术，用于筛查包括糖尿病在内的糖代谢异常。
A new non-invasive technology to screen for dysglycaemia including diabetes.
机构信息
India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals, No. 28, Marshall's Road, Egmore, Chennai 600008, India.
出版信息
Diabetes Res Clin Pract. 2010 Jun;88(3):302-6. doi: 10.1016/j.diabres.2010.01.023. Epub 2010 Feb 25.
OBJECTIVE
Assess the ability of a new device based on electrochemical principles using iontophoresis (the EZSCAN) to detect impaired glucose tolerance (IGT) and type 2 diabetes mellitus (DM).
METHODS
Eligible Asian Indian subjects, n=212, had anthropometric and blood pressure measurements, followed by an OGTT, HbA1c, serum lipids tests and EZSCAN measurement.
RESULTS
Biochemically, 24 subjects were diagnosed with DM, 30 with IGT, 57 subjects had normal glucose tolerance (NGT) with metabolic syndrome (MS) and 101 had NGT without MS. Fasting plasma glucose (FPG) and HbA1c levels were highest in the DM group (p<0.0001 for both). HDL-C levels were different (p=0.015). FPG at a cut-off level of 7.0 mmol/L had a low sensitivity to detect DM (29%) EZSCAN had a 75% sensitivity to detect DM, 70% for IGT and 84% for NGT with MS at threshold >50%.
CONCLUSIONS
FPG had low sensitivity to detect DM in the study group. EZSCAN demonstrated good sensitivity to detect IGT and DM and also identified NGT with MS. The concept of measuring ion fluxes through the skin appears to be a powerful method for early detection of MS, IGT and DM.
目的
评估一种基于电化学原理并采用离子电渗法（EZSCAN）的新型设备检测糖耐量受损（IGT）和 2 型糖尿病（DM）的能力。
方法
符合条件的亚洲印度裔受试者 212 例，进行人体测量和血压测量，然后进行 OGTT、HbA1c、血清脂质检测和 EZSCAN 测量。
结果
生化检测显示，24 例被诊断为 DM，30 例为 IGT，57 例糖耐量正常（NGT）伴代谢综合征（MS），101 例 NGT 无 MS。DM 组空腹血糖（FPG）和 HbA1c 水平最高（均 p<0.0001）。HDL-C 水平不同（p=0.015）。FPG 截断值为 7.0mmol/L 时，对 DM 的敏感性较低（29%）。EZSCAN 对 DM 的敏感性为 75%，对 IGT 的敏感性为 70%，对伴有 MS 的 NGT 的敏感性为 84%，阈值>50%。
结论
在研究组中，FPG 对 DM 的检测敏感性较低。EZSCAN 对 IGT 和 DM 的检测具有良好的敏感性，也可识别伴有 MS 的 NGT。测量皮肤离子通量的概念似乎是一种早期检测 MS、IGT 和 DM 的有效方法。
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