Food, Metabolism & Microbiology Section, AgResearch Grasslands, Tennent Drive, Palmerston North 4474, New Zealand.
Mutat Res. 2010 Aug 7;690(1-2):71-80. doi: 10.1016/j.mrfmmm.2010.02.006. Epub 2010 Feb 25.
Epigenomic regulation, via DNA methylation, histone modification and non-coding RNA, is increasingly recognised as having a key role in normal development and function of an organism, acting to control cellular and tissue growth and differentiation. It is also thought to be involved in many complex diseases now common in the Western world, including cardiovascular disease, type 2 diabetes, obesity and inflammatory bowel disease (IBD). There is a range of evidence to suggest that nutrition plays a vital role in the protection from such diseases. However, there is little information about the role of nutrition on the epigenetic regulation of IBD. This review aims to elucidate the interactions of nutrients and the epigenome in IBD. More specifically, the plasticity of epigenetic modifications that occur due to low selenium and folate levels in the diet during gestation and lactation will be discussed. A better understanding of this plasticity, and of nutrient-epigenome interactions, will have important implications for enhancing human health through foods.
表观基因组调控，通过 DNA 甲基化、组蛋白修饰和非编码 RNA，越来越被认为在生物体的正常发育和功能中起着关键作用，它可以控制细胞和组织的生长和分化。它也被认为与许多在西方世界常见的复杂疾病有关，包括心血管疾病、2 型糖尿病、肥胖和炎症性肠病（IBD）。有一系列证据表明，营养在预防此类疾病方面起着至关重要的作用。然而，关于营养在 IBD 的表观遗传调控中的作用的信息却很少。这篇综述旨在阐明营养物质与 IBD 中表观基因组的相互作用。更具体地说，将讨论由于妊娠和哺乳期饮食中硒和叶酸水平低而导致的表观遗传修饰的可塑性。更好地理解这种可塑性以及营养-表观基因组的相互作用，将对通过食物增强人类健康产生重要影响。
