Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Facultad de Medicina, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Paraguay 2155, 1121 Buenos Aires, Argentina.
J Steroid Biochem Mol Biol. 2010 Apr;119(3-5):105-11. doi: 10.1016/j.jsbmb.2010.02.015. Epub 2010 Feb 25.
During the last decade a battery of animal models used for the study of polycystic ovary syndrome (PCOS) have allowed a focus on different aspects of the pathology. Since dehydroepiandrosterone (DHEA) was found to be one of the most abundant circulating androgens in women with PCOS, a rodent model showing the salient features found in women with PCOS was developed by the injection of DHEA. Although insulin-sensitizing agents, such as biguanides, are clinically used in the treatment of diabetes and PCOS, the complete understanding of their mechanisms of action remains unknown. The present review discusses the molecular mechanisms involved in the development of PCOS by using the DHEA-PCOS murine model and analyzes the role of the biguanide metformin as treatment.
在过去的十年中，一系列用于多囊卵巢综合征（PCOS）研究的动物模型使人们能够专注于该病理学的不同方面。由于脱氢表雄酮（DHEA）被发现是多囊卵巢综合征妇女循环中最丰富的雄激素之一，因此通过注射 DHEA 开发了一种表现出多囊卵巢综合征妇女中发现的显著特征的啮齿动物模型。尽管胰岛素增敏剂，如双胍类药物，临床上用于治疗糖尿病和多囊卵巢综合征，但它们的作用机制仍不完全清楚。本综述通过使用 DHEA-PCOS 小鼠模型讨论了多囊卵巢综合征的发展所涉及的分子机制，并分析了双胍类药物二甲双胍作为治疗方法的作用。
