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核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Linn. Extract as an Innovative Strategy to Regulate Biomarkers for Ovarian Hyperthecosis via Circular RNA (hsa-circ-0001577): Evidence From Biochemical, Metabolomics, Histological, and Phytochemical Profiling.

作者信息

Ammar Naglaa M, Kadry Mai O, Abd Elkarim Asmaa S, Ibrahim Reham S, Sallam Ibrahim E, El Gendy Abd El-Nasser G, Afifi Sherif M, Esatbeyoglu Tuba, Farag Mohamed A, Elshamy Abdelsamed I

机构信息

Therapeutic Chemistry Department National Research Centre Giza Egypt.

Chemistry of Tanning Materials and Leather Technology Department National Research Centre Giza Egypt.

出版信息

Food Sci Nutr. 2025 May 19;13(5):e70314. doi: 10.1002/fsn3.70314. eCollection 2025 May.

DOI:10.1002/fsn3.70314
PMID:40395717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12091212/
Abstract

species, including Linn, are well-known vegetables whose leaves, shoots, fragile stems, and grains are commonly utilized as herbs in soups or sauces, aside from traditional uses to treat a wide range of illnesses. Ovarian hyperthecosis is a common syndrome associated with metabolomics and endocrinology that lowers female fertility. The investigation of novel biomarkers and targeted therapies for the detection and treatment of ovarian hyperthecosis is of interest. Types of noncoding RNAs known as circular RNAs (circRNAs) have covalently closed cyclic structures, are widely distributed, and exhibit expression patterns that are particular to different stages of development. Ovarian hyperthecosis was induced in rats via dehydroepiandrosterone (DHEA) followed by 1 month of treatment with 50 and 100 mg/kg of the EtOH extract. Further, oxidative stress biomarkers including GSH and MDA were investigated in addition to hormonal biomarkers, such as Luteinizing hormone and testosterone hormone, a metabolomics approach modeled using orthogonal partial least squares discriminant analysis (OPLS-DA), and circRNA (hsa-circ-0001577). Furthermore, UHPLC-ESI-Orbitrap-MS analysis was used for metabolites profiling to identify active agents in the plant extract. Results revealed a significant improvement in these biomarkers in the DHEA group treated with , especially at high doses, and further confirmed via histopathological assays. Multivariate data analyses of serum metabolome indicated significant variations in serum profiles among normal, disease, and treated groups. Variable importance in the projection (VIP) values guided the selection of differentiated metabolites, revealing significant changes in metabolite concentrations. UHPLC-ESI-Orbitrap-MS analysis identified 72 bioactive metabolites belonging to phenolics, triterpenoidal saponins, and pyridines In conclusion, could be a management approach for ovarian hyperthecosis therapy via regulating circRNA (hsa-circ-0001577), disturbed hormonal balance, and metabolomics biomarkers based assays.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/17ae54997c8f/FSN3-13-e70314-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/0cccb7b8feb0/FSN3-13-e70314-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/14be24cc04d5/FSN3-13-e70314-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/daa245a7dac6/FSN3-13-e70314-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/4623f2a9b4a4/FSN3-13-e70314-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/08ee159bdeb6/FSN3-13-e70314-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/477a1919816a/FSN3-13-e70314-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/d547c3ed37f0/FSN3-13-e70314-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/17ae54997c8f/FSN3-13-e70314-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/0cccb7b8feb0/FSN3-13-e70314-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/14be24cc04d5/FSN3-13-e70314-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/daa245a7dac6/FSN3-13-e70314-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/4623f2a9b4a4/FSN3-13-e70314-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/08ee159bdeb6/FSN3-13-e70314-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/477a1919816a/FSN3-13-e70314-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/d547c3ed37f0/FSN3-13-e70314-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b064/12091212/17ae54997c8f/FSN3-13-e70314-g008.jpg

相似文献

[1]
Linn. Extract as an Innovative Strategy to Regulate Biomarkers for Ovarian Hyperthecosis via Circular RNA (hsa-circ-0001577): Evidence From Biochemical, Metabolomics, Histological, and Phytochemical Profiling.

Food Sci Nutr. 2025-5-19

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本文引用的文献

[1]
In vivo anti-ulceration effect of Pancratium maritimum extract against ethanol-induced rats via NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-κβ signaling pathways and its extract metabolite profile.

PLoS One. 2025-4-16

[2]
Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary.

FASEB J. 2024-7-31

[3]
Enhancement of Female Rat Fertility via Ethanolic Extract from L. (Black Cumin) Seeds Assessed via HPLC-ESI-MS/MS and Molecular Docking.

Molecules. 2024-2-5

[4]
Polycystic Ovary Syndrome and Oxidative Stress-From Bench to Bedside.

Int J Mol Sci. 2023-9-15

[5]
Circular RNA as a Novel Regulator and Promising Biomarker in Polycystic Ovary Syndrome.

Biomolecules. 2023-7-11

[6]
Potentials of curcumin against polycystic ovary syndrome: Pharmacological insights and therapeutic promises.

Heliyon. 2023-6-2

[7]
Circular RNA Expression Profiling by Microarray-A Technical and Practical Perspective.

Biomolecules. 2023-4-17

[8]
The Role of Circular RNAs in the Physiology and Pathology of the Mammalian Ovary.

Int J Mol Sci. 2022-12-2

[9]
Therapeutic Investigation of Standardized Aqueous Methanolic Extract of Bitter Melon ( L.) for Its Potential against Polycystic Ovarian Syndrome in Experimental Animals' Model: and Studies.

Evid Based Complement Alternat Med. 2022-9-29

[10]
Ubiquitous toxicity of Mercuric Chloride in target tissues and organs: Impact of Ubidecarenone and liposomal-Ubidecarenone STAT 5A/ PTEN /PI3K/AKT signaling pathways.

J Trace Elem Med Biol. 2022-12

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