基于十二烷基硫酸钠在碳糊电极上的增敏效应测定抗高血压药物盐酸莫昔普利。
Determination of antihypertensive drug moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate at carbon paste electrode.
机构信息
National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.
出版信息
Talanta. 2010 Apr 15;81(1-2):25-9. doi: 10.1016/j.talanta.2009.11.031. Epub 2009 Nov 13.
Herein, an electrochemical differential pulse voltammetric method was developed for the determination of moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate. The oxidation process has been carried out in Britton-Robinson buffer. Moexipril hydrochloride exhibits a well-defined irreversible oxidation peak over the entire pH range (2-11). The peak current varied linearly over the range from 4.0 x 10(-7) to 5.2 x 10(-6) mol L(-1). The limits of detection and quantification were 6.87 x 10(-8) mol L(-1) and 2.29 x 10(-7) mol L(-1), respectively. The recovery was found in the range from 99.65% to 100.76%. The relative standard deviation was found in the range from 0.429% to 0.845%. The proposed method possesses high sensitivity, accuracy and rapid response. Finally, this method was successfully used to determine moexipril hydrochloride in tablets.
本文基于十二烷基硫酸钠的增敏效应，建立了一种测定盐酸莫昔普利的电化学差分脉冲伏安法。在 Britton-Robinson 缓冲溶液中进行了氧化过程。在整个 pH 范围（2-11）内，盐酸莫昔普利显示出明确的不可逆氧化峰。在 4.0 x 10(-7)至 5.2 x 10(-6) mol L(-1)的范围内，峰电流呈线性变化。检测限和定量限分别为 6.87 x 10(-8) mol L(-1)和 2.29 x 10(-7) mol L(-1)。回收率在 99.65%至 100.76%之间。相对标准偏差在 0.429%至 0.845%之间。该方法具有灵敏度高、准确度高、响应速度快等优点。最后，该方法成功地用于测定片剂中的盐酸莫昔普利。
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