School of Materials Science and Technology, Institute of Technology, Banaras Hindu University, Varanasi 221005, UP, India.
Talanta. 2010 Apr 15;81(1-2):449-54. doi: 10.1016/j.talanta.2009.12.023. Epub 2009 Dec 21.
Functionalization of polyanthranilic acid (PAA) a self-doped conducting polymer with Co(II) metal complex has been reported and is used in the development of azidothymidine drug sensor. For the first time synthesis of a new type of polymer complex of Co(II)-cyclam macrocyclic ligand (1,4,8,11-tetraazacyclotetradecane) with carboxylated polymer (as a second ligand) has been successfully accomplished and discussed in the present paper. The interaction of Co(II)-cyclam complex with polyanthranilic acid has been studied in solution phase using UV-vis spectra. Further, the formation and growth study of mixed ligand complex is carried out using electrochemical quartz crystal microbalance. The characterization of solid mixed ligand complex Co(II)-cyclam-polyanthranilic acid (Co(II)-Cy-PAA) has been carried out for its structural, thermal and electrochemical properties using various techniques viz. FT-IR, SEM, ESR, DSC, impedance and electrochemical techniques. Electrochemical study shows the potential of mixed ligand complex towards catalytic and sensor applications. The mixed ligand complex for the first time is used in the development of "azidothymidine" anti-HIV drug sensor. The analysis of azidothymidine is known over hanging drop mercury electrode using electroreduction technique, however, for the first time its analysis is reported over graphite paste electrode modified with newly synthesized mixed ligand complex. Azidothymidine is quantified in wide range of concentration with 1 microM detection limit over modified graphite paste electrode, which shows potential to develop users friendly (non-toxic and simple) gadgets and low cost screen printed electrodes.
聚邻苯二甲酰亚胺酸（PAA）是一种自掺杂导电聚合物，已报道其与 Co(II) 金属配合物的功能化，并用于叠氮胸苷药物传感器的开发。本文首次成功合成了新型 Co(II)-环脒大环配体（1,4,8,11-四氮杂环十四烷）与羧基化聚合物（作为第二配体）的聚合物配合物。在溶液相中使用紫外-可见光谱研究了 Co(II)-环脒配合物与聚邻苯二甲酰亚胺酸的相互作用。进一步，使用电化学石英晶体微天平进行了混合配体配合物的形成和生长研究。使用各种技术（FT-IR、SEM、ESR、DSC、阻抗和电化学技术）对固载混配配合物 Co(II)-环脒-聚邻苯二甲酰亚胺酸（Co(II)-Cy-PAA）进行了结构、热和电化学特性的表征。电化学研究表明，该混配配合物具有催化和传感器应用的潜力。首次将该混配配合物用于开发“叠氮胸苷”抗 HIV 药物传感器。已知叠氮胸苷在悬滴汞电极上通过电化学还原技术进行分析，然而，首次报道了其在新合成的混配配合物修饰的石墨糊电极上的分析。在修饰的石墨糊电极上，叠氮胸苷在很宽的浓度范围内被定量，检测限低至 1 μM，这表明有可能开发出用户友好型（无毒且简单）的小工具和低成本的丝网印刷电极。
