Pak Kyoungjune, Kim Seong-Jang, Kim In Joo, Kim Keunyoung, Kim Heeyoung, Kim So Jung
Department of Nuclear Medicine, Pusan National University Hospital, 1-10, Ami-dong, Seo-gu, Busan, Republic of Korea 602-739.
Nucl Med Mol Imaging. 2012 Sep;46(3):176-81. doi: 10.1007/s13139-012-0143-y. Epub 2012 Jun 21.
We aimed to evaluate the relation between visceral fat volume and fluorodeoxyglucose (FDG) uptake of the liver measured by maximum or mean standardized uptake value.
We retrospectively analyzed 96 consecutive records of positron emission tomography/computed tomography (PET/CT) performed for cancer screening between May 2011 and December 2011. Subjects were divided into 2 groups according to Hounsfield unit (HU) of the liver comparing with that of the spleen. The control group (20 women, 56 men) demonstrating HU of the liver equal or greater than that of the spleen included 76 patients, while the fatty liver group (2 women, 18 men) showing HU of the liver less than that of the spleen included 20 patients. We compared FDG uptake of the liver and visceral fat volume between two groups. We evaluated correlation of hepatic FDG uptake measured by maximum or mean standardized uptake value (SUV) with visceral fat volume and attenuation.
The fatty liver disease group showed higher aspartate aminotransferase (AST)of (24.42 ± 7.22, p = 0.012), alanine aminotransferase (ALT) of (25.16 ± 11.68, p = 0.001), body mass index (BMI) of (24.58 ± 3.29, p = 0.021), and visceral fat volume (3063.53 ± 1561.43, p = 0.011) than the control group. There were no statistically significant differences of mean standardized uptake value of the liver (liver SUVmean) (2.73 ± 0.19, p = 0.723), maximum standardized uptake value of the liver (liver SUVmax) (3.39 ± 0.53, p = 0.8248) and liver SUVmean/spleen SUVmean (1.13 ± 0.10, p = 0.081) between the two groups. Strong correlations were shown between liver SUVmean and BMI (r = 0.609, p < 0.001) and between liver SUVmean and visceral fat volume (r = 0.457, p < 0.001). Liver SUVmax was also strongly correlated with BMI (r = 0.622, p = 0.001) and visceral fat volume (r = 0.547, p < 0.001). There was no significant association of mean attenuation value of the liver (liver HUmean) with liver SUVmean (r = -0.003, p = 0.979) or liver SUVmax (r = -0.120, p = 0.244).
Hepatic FDG uptake quantified as SUVmean or SUVmax is not correlated with hepatic steatosis but with visceral fat volume in cancer screening.
我们旨在评估通过最大或平均标准化摄取值测量的内脏脂肪体积与肝脏氟脱氧葡萄糖（FDG）摄取之间的关系。
我们回顾性分析了2011年5月至2011年12月期间为癌症筛查进行的96例连续正电子发射断层扫描/计算机断层扫描（PET/CT）记录。根据肝脏与脾脏的Hounsfield单位（HU）将受试者分为2组。肝脏HU等于或大于脾脏的对照组（20名女性，56名男性）包括76例患者，而肝脏HU小于脾脏的脂肪肝组（2名女性，18名男性）包括20例患者。我们比较了两组之间肝脏的FDG摄取和内脏脂肪体积。我们评估了通过最大或平均标准化摄取值（SUV）测量的肝脏FDG摄取与内脏脂肪体积和衰减之间的相关性。
脂肪肝疾病组的天冬氨酸转氨酶（AST）（24.42±7.22，p = 0.012）、丙氨酸转氨酶（ALT）（25.16±11.68，p = 0.001）、体重指数（BMI）（24.58±3.29，p = 0.021）和内脏脂肪体积（3,063.53±1,561.43，p = 0.011）均高于对照组。两组之间肝脏的平均标准化摄取值（肝脏SUVmean）（2.73±0.19，p = 0.723）、肝脏的最大标准化摄取值（肝脏SUVmax）（3.39±0.53，p = 0.
