应用弥散加权成像诊断复发性中枢神经系统 Whipple 病：病例报告及文献复习。

Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease: a case report and review of the literature.

机构信息

Department of Radiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467-2401, USA.

出版信息

Clin Imaging. 2010 Mar-Apr;34(2):143-7. doi: 10.1016/j.clinimag.2009.05.011.

DOI:10.1016/j.clinimag.2009.05.011

PMID:20189080

Abstract

A case of Whipple's disease with development of antibiotic resistance is reported. The patient's symptomatology correlated with evolution of diffusion abnormality rather than with lesion enhancement. The lesion demonstrated no hyperperfusion, moderately elevated choline, and decreased N-acetylaspartate. Conventional magnetic resonance (MR) imaging findings of central nervous system Whipple's disease are nonspecific and may mimic neoplasm. MR perfusion and spectroscopy findings are reported, which may assist in diagnosis. Change in diffusion restriction appears to be a potential imaging indicator of clinical progression and response to therapy.

摘要

现报道一例发生抗生素耐药的 Whipple 病。患者的症状与弥散异常的演变相关，而非与病变强化相关。病变无高灌注，胆碱水平中度升高，N-乙酰天门冬氨酸降低。中枢神经系统 Whipple 病的常规磁共振成像（MR）表现无特异性，可能类似于肿瘤。本文报告了 MR 灌注和波谱成像的发现，这些发现可能有助于诊断。弥散受限的变化似乎是临床进展和对治疗反应的潜在影像学指标。