可降解支架用于猪模型结肠吻合术的实验研究
Experimental study of colonic anastomosis with a degradable stent in a porcine model.
作者信息
Wang YiFan, Cai XiuJun, Cai HuanJie, Liang YueLong, Huang DiYu, Liang Xiao
机构信息
Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, The Institute of Minimally Invasive Surgery, Zhejiang University, No 3, East Qinchun Rd., Hangzhou, People's Republic of China 310016.
出版信息
Am J Surg. 2010 Jun;199(6):833-9. doi: 10.1016/j.amjsurg.2009.05.044. Epub 2010 Feb 26.
BACKGROUND
Intestinal anastomosis is a major technical component of gastrointestinal procedures. We have developed a new procedure of colonic anastomosis with a degradable stent. This article evaluates this procedure.
METHODS
Forty pigs were assigned randomly to a stent group (n = 20) and a control group (n = 20). A colonic anastomosis with a degradable stent was performed in the stent group, and hand-sewn anastomosis was performed in the control group. Pigs of each group were divided evenly into 4 subgroups according to time of death (days 3, 7, and 14, and month 10 postoperatively) to evaluate the healing of anastomosis.
RESULTS
All procedures were completed successfully. The surgical time of the stent group was significantly less than the control group. No complications occurred in either group. Bursting pressure of the stent group was significantly higher than the control group on postoperative days 3 and 7. No significant difference of hydroxyproline content or microvessel density was found between the 2 groups.
CONCLUSIONS
The procedure of colonic anastomosis with a degradable stent is a simple, feasible, and safe procedure in this porcine model.
背景
肠道吻合术是胃肠手术的主要技术组成部分。我们开发了一种使用可降解支架的结肠吻合新方法。本文对该方法进行评估。
方法
40头猪被随机分为支架组（n = 20）和对照组（n = 20）。支架组进行使用可降解支架的结肠吻合术，对照组进行手工缝合吻合术。根据死亡时间（术后3天、7天、14天和10个月）将每组猪平均分为4个亚组，以评估吻合口愈合情况。
结果
所有手术均成功完成。支架组的手术时间明显短于对照组。两组均未发生并发症。术后第3天和第7天，支架组的破裂压力明显高于对照组。两组间羟脯氨酸含量或微血管密度无显著差异。
结论
在该猪模型中，使用可降解支架的结肠吻合术是一种简单、可行且安全的方法。
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