Jakobartl L, Huston J P
Physiol Behav. 1977 Nov;19(5):673-7. doi: 10.1016/0031-9384(77)90042-7.
Single waves of spreading depression (SD) were induced in freely moving Sprague Dawley rats by microinjection of KCl solution into either neocortex or caudate nucleus. DC recordings of slow potential changes (SPC) revealed that a wave of SD propagates from the neocortex to the caudate nucleus in only a very few cases (12.5% of trials, involving 4.3% of the SPC waves). This result contrasts with earlier reported higher incidences of neocortical-striatal transmission of SD, and suggests that such transmission may vary across rat strains. Invasion of the caudate nucleus by a wave of neocortical SD was accompanied by contralateral circling in 50% of the cases. Similarly, SD induced by injection of KCl into the striatum was accompanied by circling in 43% of trials. It was also found that neocortical SD-induced feeding generally occurred only upon recovery of neocortex from the slow potential negativity, and that invasion of the caudate nucleus by SD is not involved in the elicited feeding phenomenon.
通过向自由活动的斯普拉格-道利大鼠的新皮层或尾状核微量注射氯化钾溶液，诱发了单波扩散性抑制（SD）。慢电位变化（SPC）的直流记录显示，只有极少数情况下（12.5%的试验，涉及4.3%的SPC波），SD波才会从新皮层传播到尾状核。这一结果与早期报道的SD从新皮层向纹状体传播的较高发生率形成对比，表明这种传播可能因大鼠品系而异。在50%的情况下，新皮层SD波侵入尾状核会伴随着对侧转圈。同样，向纹状体注射氯化钾诱发的SD在43%的试验中伴随着转圈。还发现，新皮层SD诱发的进食通常只在新皮层从慢电位负性恢复时才会发生，并且SD侵入尾状核与引发的进食现象无关。
