Wong L C, Choo Y C, Ma H K
Am J Obstet Gynecol. 1985 May 1;152(1):59-62. doi: 10.1016/s0002-9378(85)80178-2.
Thirty-three patients with gestational trophoblastic disease treated with methotrexate alone and 68 similar patients treated with methotrexate and citrovorum factor rescue were analyzed. Both groups showed a comparable sustained biochemical remission rate. The group treated with methotrexate and citrovorum factor however showed a shorter interval to induction of remission (p less than 0.05). Contrary to previous reports, the methotrexate and citrovorum factor regimen failed to protect the patients against the development of hepatic toxicity, the incidence of hepatic toxicity being significantly higher in the group treated with methotrexate and citrovorum factor.
对33例仅用甲氨蝶呤治疗的妊娠滋养细胞疾病患者和68例接受甲氨蝶呤及亚叶酸钙解救治疗的类似患者进行了分析。两组的持续生化缓解率相当。然而，接受甲氨蝶呤及亚叶酸钙治疗的组达到缓解的诱导间隔更短（P<0.05）。与先前的报道相反，甲氨蝶呤及亚叶酸钙方案未能保护患者预防肝毒性的发生，接受甲氨蝶呤及亚叶酸钙治疗组的肝毒性发生率显著更高。
