Scoliosis Research Center, Orthopedic Department, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Med Hypotheses. 2010 Jul;75(1):126-7. doi: 10.1016/j.mehy.2010.02.006. Epub 2010 Feb 26.
The pathogenesis of adolescent idiopathic scoliosis (AIS) remains little understood. Previous work has shown that guppy fish is an ideal animal model of idiopathic scoliosis which has similar epidemiological and morphological characteristic with AIS. However, some research speculated that the high-selenium environment could also induce idiopathic-type scoliosis of fish. We believe that the high-selenium related deformity of spine and guppy curveback syndrome may have the same pathogenesis. And high selenium may be a risk factor of AIS.
青少年特发性脊柱侧凸（AIS）的发病机制仍知之甚少。先前的研究表明，孔雀鱼是特发性脊柱侧凸的理想动物模型，其具有与 AIS 相似的流行病学和形态学特征。然而，一些研究推测，高硒环境也可能导致鱼类特发性脊柱侧凸。我们认为，脊柱高硒相关畸形和孔雀鱼驼背综合征可能具有相同的发病机制，而高硒可能是 AIS 的一个危险因素。
