Rao N Srinivasa, Raju G J Naga, Tiwari M K, Naidu B G, Sarita P
Department of Physics, GIS, GITAM Deemed To Be University, Visakhapatnam, 530045, India.
Department of Physics, UCEV- JNTUK, Vizianagaram, 535003, India.
Biol Trace Elem Res. 2022 Apr;200(4):1485-1494. doi: 10.1007/s12011-021-02762-7. Epub 2021 Jun 2.
A total of 158 serum samples of newly diagnosed type 2 diabetes patients and control subjects were analyzed using Synchrotron Radiation X-ray Fluorescence (SRXRF) technique. The microprobe XRF beam line-16 of Indus-2 synchrotron radiation facility at Raja Ramanna Centre for Advanced Technology (RRCAT), Indore, India, was used to identify and quantify the elements K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Br, Rb, Sr, and Pb. A significant decrease in the mean concentrations of K, Ca, Ti, Cr, Mn, Ni, Zn, and As and an increase in the concentrations of V, Fe, Co, Cu, Se, and Pb were observed in the serum samples of the patient group when compared to the control group. It is hypothesized that the observed alterations in the elemental concentrations might have led to ineffective uptake of insulin and have interfered with glucose homeostasis by either directly or indirectly causing oxidative stress.
使用同步辐射X射线荧光（SRXRF）技术对158份新诊断的2型糖尿病患者和对照受试者的血清样本进行了分析。位于印度印多尔拉贾·拉曼纳先进技术中心（RRCAT）的Indus-2同步辐射设施的微探针X射线荧光束线-16，用于识别和定量元素钾（K）、钙（Ca）、钛（Ti）、钒（V）、铬（Cr）、锰（Mn）、铁（Fe）、钴（Co）、镍（Ni）、铜（Cu）、锌（Zn）、砷（As）、硒（Se）、溴（Br）、铷（Rb）、锶（Sr）和铅（Pb）。与对照组相比，患者组血清样本中K、Ca、Ti、Cr、Mn、Ni、Zn和As的平均浓度显著降低，而V、Fe、Co、Cu、Se和Pb的浓度升高。据推测，观察到的元素浓度变化可能导致胰岛素摄取无效，并通过直接或间接引起氧化应激干扰葡萄糖稳态。
