Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Eur Rev Med Pharmacol Sci. 2013 Sep;17(18):2499-503.
Scoliosis is the disease which has a long history over one century. However, the pathogenesis remains unclear at present. To demonstrate the effect of different selenium content in environment on the morbidity of adolescent idiopathic scoliosis (AIS).
Retrospective cohort study (follow-up from 1997 to 2009): compare the difference morbidity between high selenium group and the normal selenium group of AIS.
9998 cases from three areas in China were participated in this study. There is different selenium content in these three areas.
High selenium levels were significant associated with the AIS morbidity. While low selenium level had no significant correlation with the AIS morbidity.
This study confirmed that high selenium content in the environment was one of risk factors for idiopathic scoliosis. We speculated that the excessive growth of the spine and the spinal cord asynchronous growth effect were key factors that high selenium content in the environment leads to scoliosis.
脊柱侧凸是一种具有百余年历史的疾病。然而，目前其发病机制尚不清楚。本研究旨在探讨环境中不同硒含量对青少年特发性脊柱侧凸（AIS）发病率的影响。
回顾性队列研究（随访时间 1997 年至 2009 年）：比较高硒组和正常硒组 AIS 的发病率差异。
本研究共纳入中国三个地区的 9998 例患者，这三个地区的硒含量不同。
高硒水平与 AIS 发病率显著相关，而低硒水平与 AIS 发病率无显著相关性。
本研究证实环境中高硒含量是特发性脊柱侧凸的危险因素之一。我们推测，环境中高硒含量导致脊柱过度生长和脊髓与脊柱不同步生长的效应是导致脊柱侧凸的关键因素。
