Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, University of Berne, Berne, Switzerland.
Oral Oncol. 2010 Apr;46(4):287-91. doi: 10.1016/j.oraloncology.2010.01.011. Epub 2010 Feb 26.
We report our experience on the diagnostic approach, treatment, and follow-up of primary submandibular gland tumors. Retrospective review. Tertiary referral center. Forty-one adult patients, 22 male and 19 female, with primary submandibular gland tumors, 20 benign and 21 malignant. Age, gender, clinical findings, cyto- and histopathology, treatment and outcome were analyzed. Most tumors presented as a painless submandibular mass. Thirty three patients underwent a fine needle aspiration, the sensitivity, specificity and accuracy of which--in detecting malignant tumors--were 79%, 100% and 88%, respectively. Preoperative radiological imaging was performed in 30 cases. Patients with benign tumors were treated with surgery. Most malignant tumors were treated with a combined modality, including neck dissection and radiation therapy. Five patients developed a postoperative complication. Recurrent disease was encountered in 5 malignant tumors. The 2, 5 and 10 year disease-specific survival of patients with malignancy were 84%, 75% and 41%, respectively. The preoperative assessment of the nature of submandibular gland tumors remains challenging. Aggressive treatment of patients with malignant disease may help to avoid poor prognosis.
我们报告了原发性下颌下腺肿瘤的诊断方法、治疗和随访经验。回顾性研究。三级转诊中心。41 例成年患者，22 例男性，19 例女性，原发性下颌下腺肿瘤 20 例良性，21 例恶性。分析了年龄、性别、临床发现、细胞病理学和组织病理学、治疗和结果。大多数肿瘤表现为无痛性下颌下肿块。33 例患者接受了细针穿刺，其检测恶性肿瘤的敏感性、特异性和准确性分别为 79%、100%和 88%。30 例患者进行了术前影像学检查。良性肿瘤患者行手术治疗。大多数恶性肿瘤采用联合治疗，包括颈清扫术和放射治疗。5 例患者术后发生并发症。5 例恶性肿瘤出现复发病例。恶性肿瘤患者的 2、5 和 10 年疾病特异性生存率分别为 84%、75%和 41%。下颌下腺肿瘤性质的术前评估仍然具有挑战性。对恶性疾病患者的积极治疗可能有助于避免不良预后。
