Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, J.B. Winsloews Vej 4, 5000, Odense C, Denmark.
Faculty of Health Sciences, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Eur Arch Otorhinolaryngol. 2023 Jul;280(7):3405-3413. doi: 10.1007/s00405-023-07940-y. Epub 2023 Apr 13.
The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma.
All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression.
The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11-102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates.
The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.
本研究旨在基于丹麦全国患者队列，介绍唾液腺癌的发病率、组织学亚型、生存率和预后因素。
纳入 1990 年至 2015 年间诊断为下颌下腺癌的所有丹麦患者（n=206），并进行组织学重新评估。数据由丹麦头颈部癌症组（DAHANCA）收集。总体上评估了疾病特异性和无复发生存率。使用多变量 Cox 风险回归分析了预后因素。
研究人群包括 109 名男性（53%）和 97 名女性（47%），中位年龄为 62 岁（范围 11-102 岁）。腺样囊性癌是最常见的亚型（50%）。肿瘤分类 T1/T2（75%）和 N0（78%）最常见。粗发病率的平均值为 0.17/100,000/年。大多数患者（n=194，94%）接受了原发性手术治疗，130 例（67%）接受了术后放疗。总生存率、疾病特异性生存率和无复发生存率分别为 5 年时 64%、41%和 70%，10 年时 41%、61%和 56%。与其他亚型相比，腺样囊性癌的生存率较高，但在多变量分析中差异无统计学意义。69 例患者出现复发，其中 37 例（53.6%）发生远处转移。高级 T 分类和区域淋巴结转移对生存率有显著的负面影响。
丹麦下颌下腺癌的发病率为 0.17/100,000/年，在研究期间保持稳定。最常见的亚型是腺样囊性癌。一半的复发发生在远处，多变量分析证实晚期是复发和生存的独立预后不良因素。
