Department of Neurology, Jacobs Neurological Institute, State University of New York-Buffalo, 100 High Street, Buffalo, NY 14203, USA.
J Neurol Sci. 2010 May 15;292(1-2):5-10. doi: 10.1016/j.jns.2010.02.004. Epub 2010 Mar 1.
Multiple sclerosis is an autoimmune demyelinating disorder of the central nervous system. Its etiology continues to be elucidated. The debate about the environmental impact on the disease etiology and progression has focused on sun light exposure in the recent past, but mainly as it applies to vitamin D and its derivatives. This paper will discuss how sunlight stimulus may effect neuronal and microglial antigenic presentation based on sunlight-dependent neuronal activity, as well as how sunlight may alter the amount of vitamin A and melatonin levels during immune development in the central nervous system. Changes in the number of antigens presented to lymphocytes by antigen-presenting cells for self-selective removal during immune development could therefore alter the number of circulating self-recognizing B and T-lymphocytes. This situation would increase susceptibility to a significantly greater number of self-antigens, and lead to autoimmune disorders such as multiple sclerosis.
多发性硬化症是一种中枢神经系统的自身免疫脱髓鞘疾病。其病因仍在阐明中。关于环境对疾病病因和进展的影响的争论，最近主要集中在阳光照射上，主要是因为它与维生素 D 及其衍生物有关。本文将讨论阳光刺激如何根据阳光依赖的神经元活性影响神经元和小胶质细胞的抗原呈递，以及阳光如何在中枢神经系统的免疫发育过程中改变维生素 A 和褪黑素的水平。因此，抗原呈递细胞向淋巴细胞呈递的抗原数量的变化，可能会改变循环中自我识别的 B 和 T 淋巴细胞的数量。这种情况会增加对大量自身抗原的易感性，并导致自身免疫性疾病，如多发性硬化症。
