高石竹中的三萜皂苷

Triterpenoid saponins from Gypsophila altissima L.

作者信息

Chen Qing, Luo Jian-Guang, Kong Ling-Yi

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

出版信息

Chem Pharm Bull (Tokyo). 2010 Mar;58(3):412-4. doi: 10.1248/cpb.58.412.

DOI:10.1248/cpb.58.412

PMID:20190453

Abstract

Two new triterpenoid saponins (1, 2) were isolated from the roots of Gypsophila altissima L. (Caryophyllaceae), together with a known compound (3). The structures of new saponins were established as quillaic acid 3-O-beta-D-xylopyranosyl-(1-->3)-beta-D-glucuronopyranoside (1), and 3-O-beta-D-galactopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucuronopyranosyl quillaic acid 28-O-(6-O-acetyl)-beta-D-glucopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranoside (2), on the basis of various spectroscopic analyses (including heteronuclear single quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), nuclear Overhauser effect spectroscopy (NOESY), total correlation spectroscopy (TOCSY), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS)) and chemical degradations.

摘要

从高雪轮（石竹科）的根部分离出两种新的三萜皂苷（1, 2）以及一种已知化合物（3）。通过各种光谱分析（包括异核单量子相关（HSQC）、异核多键相关（HMBC）、核Overhauser效应光谱（NOESY）、全相关光谱（TOCSY）和高分辨率电喷雾电离质谱（HR-ESI-MS））和化学降解，确定新皂苷的结构为齐墩果酸3 - O - β - D - 吡喃木糖基 -（1→3）- β - D - 吡喃葡萄糖醛酸苷（1）和3 - O - β - D - 吡喃半乳糖基 -（1→2）-[β - D - 吡喃木糖基 -（1→3）]- β - D - 吡喃葡萄糖醛酸基齐墩果酸28 - O -（6 - O - 乙酰基）- β - D - 吡喃葡萄糖基 -（1→3）-[β - D - 吡喃木糖基 -（1→4）]- α - L - 鼠李吡喃糖基 -（1→2）- β - D - 岩藻吡喃糖苷（2）。