苯溴马隆所致药物性嗜酸性粒细胞性肺炎伴肺泡出血

Drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benzbromarone.

作者信息

Hara Atsuko, Mukae Hiroshi, Hara Shintaro, Amenomori Misato, Ishimoto Hiroshi, Kakugawa Tomoyuki, Fujita Hanako, Sakamoto Noriho, Ishii Hiroshi, Ishimatsu Yuji, Kohno Shigeru

机构信息

Second Department of Internal Medicine, Nagasaki University School of Medicine.

出版信息

Intern Med. 2010;49(5):435-8. doi: 10.2169/internalmedicine.49.2830. Epub 2010 Mar 1.

DOI:10.2169/internalmedicine.49.2830

PMID:20190479

Abstract

A 51-year-old man was admitted to our hospital with cough, hemosputum, dyspnea and chest pain. Chest high-resolution computed tomography (HRCT) revealed diffuse ground-glass opacities in both lungs with peripheral predominance. Bronchoalveolar lavage fluid was fresh-bloody and analysis indicated an increase in the eosinophil proportion. Benzbromarone-induced lymphocyte stimulation test was positive. Therefore, the patient was diagnosed as having drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benzbromarone. After discontinuation of benzbromarone and administration of corticosteroids, chest HRCT images and respiratory manifestation improved. Here, we report this rare case of benzbromarone-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage.

摘要

一名51岁男性因咳嗽、咯血、呼吸困难和胸痛入院。胸部高分辨率计算机断层扫描（HRCT）显示双肺弥漫性磨玻璃影，以外周为主。支气管肺泡灌洗液为血性，分析显示嗜酸性粒细胞比例增加。苯溴马隆诱导的淋巴细胞刺激试验呈阳性。因此，该患者被诊断为苯溴马隆引起的药物性嗜酸性粒细胞性肺炎伴肺泡出血。停用苯溴马隆并给予糖皮质激素治疗后，胸部HRCT图像和呼吸症状有所改善。在此，我们报告这例罕见的苯溴马隆引起的嗜酸性粒细胞性肺炎伴肺泡出血病例。