Serial monitoring of basal metabolic rate for therapeutic evaluation in an Isaacs' syndrome patient with chronic fluctuating symptoms.

A 52-year-old man presented with hyperhydrosis, painful pseudomyotonia and gait disturbance. The condition was diagnosed as Isaacs' syndrome on the basis of characteristic findings noted on an electromyogram. Carbamazepine treatment was only partially and transiently effective. Intravenous immunoglobulin therapy was effective. The basal metabolic rate (BMR) was serially monitored using an automatic integrated system for breath analysis. Serial monitoring of the BMR facilitates therapeutic evaluation in an Isaacs' syndrome patient with chronic fluctuating symptoms.