Dhand Upinder K
Department of Neurology, University of Missouri, M178, Columbia, Missouri 65212, USA.
Muscle Nerve. 2006 Nov;34(5):646-50. doi: 10.1002/mus.20591.
A patient with Isaacs' syndrome had generalized muscle spasms, twitching, and progressive muscle stiffness for 21 years. Electrodiagnostic study showed continuous spontaneous motor-unit activity and the presence of M-wave afterdischarges. He responded dramatically to treatment with carbamazepine but developed a drug rash; his treatment was changed to gabapentin with continued improvement. Subsequent nerve conduction studies showed decreased amplitude and later an absence of M-wave afterdischarges. Gabapentin thus appears to be an effective treatment for Isaacs' syndrome.
