Shintani Yasushi, Ohta Mitsunori, Iwasaki Teruo, Ikeda Naoki, Tomita Emiko, Nagano Teruaki, Kawahara Kunimitsu
Departments of Thoracic Surgery and Pathology, Osaka Prefectural Hospital Organization, Osaka Prefectural Medical Center for Respiratory and Allergic Disease, 3-7-1 Habikino, Osaka, Japan.
Ann Thorac Cardiovasc Surg. 2010 Aug;16(1):45-7.
Micronodular pneumocyte hyperplasia (MNPH) is often associated with tuberous sclerosis complex and/or lymphangioleiomyomatosis. We present the case of a 45-year-old woman with MNPH without evidence of either. A preoperative high-resolution chest computed topographic scan demonstrated a ground-glass opacity 8 mm in diameter that revealed the possibility of atypical adenomatous hyperplasia (AAH) or bronchioloalveolar carcinoma (BAC). Therefore an S3 segmentectomy of the right lung was performed, and the specimens revealed the characteristic histological and immunohistological features of MNPH. Solitary MNPH is extremely rare and requires to be distinguished from AAH or BAC on a computed tomographic scan; therefore surgical resection may be required to definitely rule out malignancy.
微小结节性肺细胞增生（MNPH）常与结节性硬化症复合体和/或淋巴管平滑肌瘤病相关。我们报告一例45岁女性患有MNPH，但无上述两种疾病的证据。术前高分辨率胸部计算机断层扫描显示一个直径8毫米的磨玻璃影，提示可能为不典型腺瘤样增生（AAH）或细支气管肺泡癌（BAC）。因此，对右肺进行了S3段切除术，标本显示出MNPH的特征性组织学和免疫组织学特征。孤立性MNPH极为罕见，在计算机断层扫描上需要与AAH或BAC相鉴别；因此可能需要手术切除以明确排除恶性肿瘤。
