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Chemotherapy: Gemcitabine remains the standard of care for pancreatic cancer.

作者信息

Berlin Jordan, Benson Al B

出版信息

Nat Rev Clin Oncol. 2010 Mar;7(3):135-7. doi: 10.1038/nrclinonc.2010.16.

DOI:10.1038/nrclinonc.2010.16
PMID:20190797
Abstract
摘要

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1
Chemotherapy: Gemcitabine remains the standard of care for pancreatic cancer.化疗：吉西他滨仍是胰腺癌的标准治疗方案。
Nat Rev Clin Oncol. 2010 Mar;7(3):135-7. doi: 10.1038/nrclinonc.2010.16.
2
[Gemzar (gemcitabine)--a new chemotherapeutic agent for pancreatic cancer].健择（吉西他滨）——一种用于胰腺癌的新型化疗药物
Harefuah. 1997 Sep;133(5-6):208-12.
3
FDA expands access to gemcitabine for pancreatic cancer.美国食品药品监督管理局扩大了吉西他滨用于治疗胰腺癌的可及范围。
Am J Health Syst Pharm. 1995 May 1;52(9):931. doi: 10.1093/ajhp/52.9.931.
4
Gemcitabine doublets in advanced pancreatic cancer: should we move on?晚期胰腺癌中的吉西他滨双联方案：我们是否应继续采用？
J Clin Oncol. 2006 Jan 20;24(3):327-9. doi: 10.1200/JCO.2005.03.8315. Epub 2005 Dec 12.
5
Gemcitabine for pancreatic cancer: how hard to look for clinical benefit? An American perspective.吉西他滨用于胰腺癌：寻找临床获益有多难？美国视角。
Ann Oncol. 1996 Apr;7(4):335-7. doi: 10.1093/oxfordjournals.annonc.a010597.
6
Will gemcitabine monotherapy be dethroned as the adjuvant chemotherapy in pancreatic adenocarcinoma?吉西他滨单药疗法会被取代，不再作为胰腺腺癌的辅助化疗方案吗？
Future Oncol. 2017 Feb;13(3):197-199. doi: 10.2217/fon-2016-0316. Epub 2016 Sep 14.
7
Adjuvant chemotherapy with gemcitabine for patients with resectable pancreatic cancer.吉西他滨辅助化疗用于可切除胰腺癌患者。
JAMA. 2007 Jun 20;297(23):2581-2; author reply 2582. doi: 10.1001/jama.297.23.2581-b.
8
ODAC recommends full approval for Gemzar for pancreatic cancer.肿瘤药物咨询委员会建议完全批准健择用于治疗胰腺癌。
Oncology (Williston Park). 1995 Sep;9(9):799-800.
9
Second-line therapy in gemcitabine-pretreated patients with advanced pancreatic cancer.吉西他滨预处理的晚期胰腺癌患者的二线治疗
J Clin Oncol. 2008 Mar 1;26(7):1178-9; author reply 1179. doi: 10.1200/JCO.2007.15.3304.
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[Gemcitabine chemotherapy for patients with advanced or relapsed pancreatic cancer].[吉西他滨化疗用于晚期或复发胰腺癌患者]
Nihon Rinsho. 2006 Jan;64 Suppl 1:198-202.

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Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway.甘氨酸脱羧酶通过干扰素刺激基因因子3介导的途径调节肾癌进展。
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Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients.吉西他滨用于范可尼贫血患者头颈部癌的化疗。
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本文引用的文献

1
Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment.美国国立癌症研究所胰腺癌治疗临床试验规划会议共识报告。
J Clin Oncol. 2009 Nov 20;27(33):5660-9. doi: 10.1200/JCO.2009.21.9022. Epub 2009 Oct 26.
2
Changing the paradigm in conducting randomized clinical studies in advanced pancreatic cancer: an opportunity for better clinical development.改变晚期胰腺癌随机临床研究的模式：实现更好临床进展的契机。
J Clin Oncol. 2009 Nov 20;27(33):5487-91. doi: 10.1200/JCO.2009.23.3098. Epub 2009 Oct 26.
3
Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer.
RNA 修饰和长非编码 RNA 相互作用在癌症中的新兴作用。
Cancer Gene Ther. 2024 Jun;31(6):816-830. doi: 10.1038/s41417-024-00734-2. Epub 2024 Feb 14.
4
Bioprinting of hydrogel beads to engineer pancreatic tumor-stroma microtissues for drug screening.用于药物筛选的水凝胶微珠生物打印以构建胰腺肿瘤-基质微组织
Int J Bioprint. 2023 Feb 1;9(3):676. doi: 10.18063/ijb.676. eCollection 2023.
5
Regulation of pancreatic cancer therapy resistance by chemokines.趋化因子对胰腺癌治疗耐药性的调控
Semin Cancer Biol. 2022 Nov;86(Pt 2):69-80. doi: 10.1016/j.semcancer.2022.08.010. Epub 2022 Sep 2.
6
CASC9 potentiates gemcitabine resistance in pancreatic cancer by reciprocally activating NRF2 and the NF-κB signaling pathway.CASC9通过相互激活NRF2和NF-κB信号通路增强胰腺癌对吉西他滨的耐药性。
Cell Biol Toxicol. 2023 Aug;39(4):1549-1560. doi: 10.1007/s10565-022-09746-w. Epub 2022 Aug 1.
7
Development of gemcitabine-resistant patient-derived xenograft models of pancreatic ductal adenocarcinoma.吉西他滨耐药的胰腺导管腺癌患者来源异种移植模型的建立。
Cancer Drug Resist. 2020;3(3):572-585. doi: 10.20517/cdr.2020.35. Epub 2020 Aug 7.
8
Evaluation of NUC-1031: a first-in-class ProTide in biliary tract cancer.评估 NUC-1031：一种胆管癌的首创类 ProTide。
Cancer Chemother Pharmacol. 2020 Jun;85(6):1063-1078. doi: 10.1007/s00280-020-04079-z. Epub 2020 May 21.
9
Impact of ethanolic extract of (EA1) on pancreatic carcinoma AsPC-1 cells.（EA1）乙醇提取物对胰腺癌AsPC-1细胞的影响。
Saudi J Biol Sci. 2020 May;27(5):1260-1264. doi: 10.1016/j.sjbs.2020.01.029. Epub 2020 Jan 30.
10
Quantitation of deoxynucleoside triphosphates by click reactions.通过点击反应定量脱氧核苷三磷酸。
Sci Rep. 2020 Jan 17;10(1):611. doi: 10.1038/s41598-020-57463-3.
吉西他滨对比吉西他滨联合卡培他滨治疗晚期胰腺癌的 III 期随机对照研究。
J Clin Oncol. 2009 Nov 20;27(33):5513-8. doi: 10.1200/JCO.2009.24.2446. Epub 2009 Oct 26.
4
Cancer statistics, 2009.2009年癌症统计数据。
CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49. doi: 10.3322/caac.20006. Epub 2009 May 27.
5
Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group.吉西他滨联合卡培他滨与单用吉西他滨治疗晚期胰腺癌的比较：瑞士临床癌症研究组和中欧肿瘤协作组的一项随机、多中心、III期试验
J Clin Oncol. 2007 Jun 1;25(16):2212-7. doi: 10.1200/JCO.2006.09.0886.
6
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.厄洛替尼联合吉西他滨与吉西他滨单药治疗晚期胰腺癌患者的比较：加拿大国家癌症研究所临床试验组的一项III期试验
J Clin Oncol. 2007 May 20;25(15):1960-6. doi: 10.1200/JCO.2006.07.9525. Epub 2007 Apr 23.
7
Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: a randomized phase II trial.转移性胰腺腺癌患者每两周接受单剂量或联合卡培他滨的高剂量吉西他滨治疗：一项随机II期试验。
Ann Oncol. 2003 Jan;14(1):97-104. doi: 10.1093/annonc/mdg029.