在患有金黄色葡萄球菌慢性感染的奶牛泌乳期使用头孢匹林钠进行为期5天的延长治疗方案的疗效。
Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus.
作者信息
Roy Jean-Philippe, DesCôteaux Luc, DuTremblay Denis, Beaudry Francis, Elsener Johanne
机构信息
Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, 3200, rue Sicotte, CP 5000, St-Hyacinthe, Québec, Canada.
出版信息
Can Vet J. 2009 Dec;50(12):1257-62.
This study determined the efficacy of a 5-day extended therapy with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus. Chronically infected cows selected from 14 dairy herds in the St-Hyacinthe region, Québec were randomly allocated to a group of 31 cows treated for 5 consecutive days with 200 mg of cephapirin per quarter BID or a group of 30 untreated control cows. Bacteriological cure was determined by 3 negative bacterial cultures at 10, 24, and 31 days after treatment. The cow cure rates were 25.8% (8/31) in the treated cows and 3.3% (1/30) in the control group (P = 0.013). The quarter cure rates at first sampling post-treatment were 77.6% (38/49) and 18% (9/50) in the treated and the control groups, respectively (P < 0.0001). A 5-day extended therapy with cephapirin is effective in treating cows chronically infected with S. aureus.
本研究确定了头孢匹林钠5天延长疗法对慢性感染金黄色葡萄球菌的奶牛的疗效。从魁北克圣亚森特地区的14个奶牛群中挑选出的慢性感染奶牛被随机分为两组，一组31头奶牛，每季度每天两次，每次200毫克头孢匹林，连续治疗5天；另一组30头奶牛作为未治疗的对照组。通过治疗后10天、24天和31天的3次阴性细菌培养来确定细菌学治愈情况。治疗组奶牛的治愈率为25.8%（8/31），对照组为3.3%（1/30）（P = 0.013）。治疗后首次采样时，治疗组和对照组的季度治愈率分别为77.6%（38/49）和18%（9/50）（P < 0.0001）。头孢匹林5天延长疗法对治疗慢性感染金黄色葡萄球菌的奶牛有效。
Zotero 插件