Roy Jean-Philippe, DesCôteaux Luc, DuTremblay Denis, Beaudry Francis, Elsener Johanne
Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, 3200, rue Sicotte, CP 5000, St-Hyacinthe, Québec, Canada.
Can Vet J. 2009 Dec;50(12):1257-62.
This study determined the efficacy of a 5-day extended therapy with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus. Chronically infected cows selected from 14 dairy herds in the St-Hyacinthe region, Québec were randomly allocated to a group of 31 cows treated for 5 consecutive days with 200 mg of cephapirin per quarter BID or a group of 30 untreated control cows. Bacteriological cure was determined by 3 negative bacterial cultures at 10, 24, and 31 days after treatment. The cow cure rates were 25.8% (8/31) in the treated cows and 3.3% (1/30) in the control group (P = 0.013). The quarter cure rates at first sampling post-treatment were 77.6% (38/49) and 18% (9/50) in the treated and the control groups, respectively (P < 0.0001). A 5-day extended therapy with cephapirin is effective in treating cows chronically infected with S. aureus.
本研究确定了头孢匹林钠5天延长疗法对慢性感染金黄色葡萄球菌的奶牛的疗效。从魁北克圣亚森特地区的14个奶牛群中挑选出的慢性感染奶牛被随机分为两组，一组31头奶牛，每季度每天两次，每次200毫克头孢匹林，连续治疗5天；另一组30头奶牛作为未治疗的对照组。通过治疗后10天、24天和31天的3次阴性细菌培养来确定细菌学治愈情况。治疗组奶牛的治愈率为25.8%（8/31），对照组为3.3%（1/30）（P = 0.013）。治疗后首次采样时，治疗组和对照组的季度治愈率分别为77.6%（38/49）和18%（9/50）（P < 0.0001）。头孢匹林5天延长疗法对治疗慢性感染金黄色葡萄球菌的奶牛有效。
