Han Rongwei, Li Songli, Wang Jun, Yu Zhongna, Wang Jiaqi, Zheng Nan
College of Food Science and Technology, Qingdao Agricultural University, Qingdao, P. R. China.
State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P. R. China.
PLoS One. 2017 Nov 2;12(11):e0187261. doi: 10.1371/journal.pone.0187261. eCollection 2017.
Ceftiofur hydrochloride (CEF) is occasionally used for the intramammary (IMM) treatment of mastitis. This extralabel manner could result in a drug-residue violation of the milk. The objective of this study was to determine the elimination kinetics of IMM CEF in lactating dairy cattle. The pharmacokinetic profile of CEF after repeated IMM administration in nine healthy cows and nine Staphylococcus aureus infected cows was investigated, alongside determining the MICs of Staph. aureus field strains. The MIC 90 value for CEF in Staph. aureus field strains (n = 31) was 0.25 μg/mL. The t >MIC CEF values for low- production quarters were longer than those for high- and mid- production quarters. The results showed that ceftiofur was detected in milk up to 108 h after the last infusion in both healthy and infected cows. Cows with low milk production eliminate IMM drugs more slowly than cows with higher production. Our findings suggest that this extralabel use is not encouraged and a prudent use is recommended for mastitis therapy. The use of CEF should be reserved for infections where susceptibility tests indicate its efficacy and when alternatives are not available.
盐酸头孢噻呋（CEF）偶尔用于乳腺炎的乳房内（IMM）治疗。这种超说明书用药方式可能导致牛奶出现药物残留违规问题。本研究的目的是确定哺乳期奶牛乳房内注射CEF后的消除动力学。研究了9头健康奶牛和9头感染金黄色葡萄球菌的奶牛重复乳房内注射CEF后的药代动力学特征，同时测定了金黄色葡萄球菌田间菌株的最低抑菌浓度（MIC）。金黄色葡萄球菌田间菌株（n = 31）对CEF的MIC90值为0.25μg/mL。低产乳腺区的CEF t>MIC值高于高产和中产乳腺区。结果表明，在健康奶牛和感染奶牛最后一次注射后108小时内，牛奶中均检测到头孢噻呋。产奶量低的奶牛比产奶量高的奶牛消除乳房内注射药物的速度更慢。我们的研究结果表明，不鼓励这种超说明书用药方式，建议谨慎用于乳腺炎治疗。CEF应仅用于药敏试验表明其有效的感染情况以及没有其他替代药物时。
