Tsubota K, Chiba K, Shimazaki J
Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
Cornea. 1991 Mar;10(2):156-60. doi: 10.1097/00003226-199103000-00011.
The corneal epithelia of phakic control (n = 13), aphakic control (n = 10), diabetic phakic (n = 10), and diabetic aphakic patients (n = 13) were surveyed under a wide-field specular microscope with a special contact lens. In control patients, the corneal epithelium showed relatively hexagonal cells, which we divided into three groups: bright cells, medium-bright cells, and dark cells. These epithelial cells displayed a smooth-surface configuration. In diabetic phakic patients, the epithelium seemed almost normal, with slightly more irregularity. In diabetic aphakic patients, the epithelium appeared larger. The cells were irregular and easy to distinguish from normal cells. Morphometric analysis showed that the mean cell areas of phakic control, aphakic control, diabetic phakic, and diabetic aphakic patients were 648 +/- 152, 643 +/- 125, 658 +/- 146, and 821 +/- 203 microns 2, respectively. The increase in the average cell area in diabetic aphakic patients was statistically significant. Although no apparent changes of the epithelium could be detected in the diabetic corneal epithelium under biomicroscopy, abnormalities that could be evaluated by specular microscopic images and morphometric analysis were observed.
使用特殊隐形眼镜，在广角镜面显微镜下对有晶状体对照患者（n = 13）、无晶状体对照患者（n = 10）、糖尿病有晶状体患者（n = 10）和糖尿病无晶状体患者（n = 13）的角膜上皮进行了观察。在对照患者中，角膜上皮显示出相对呈六边形的细胞，我们将其分为三组：亮细胞、中等亮度细胞和暗细胞。这些上皮细胞呈现出表面光滑的形态。在糖尿病有晶状体患者中，上皮似乎几乎正常，但略有更多不规则性。在糖尿病无晶状体患者中，上皮显得更大。细胞不规则，易于与正常细胞区分开来。形态计量学分析表明，有晶状体对照、无晶状体对照、糖尿病有晶状体和糖尿病无晶状体患者的平均细胞面积分别为648±152、643±125、658±146和821±203平方微米。糖尿病无晶状体患者平均细胞面积的增加具有统计学意义。尽管在生物显微镜下未检测到糖尿病角膜上皮有明显变化，但通过镜面显微镜图像和形态计量学分析观察到了可评估的异常情况。
