Tsubota K, Hata S, Toda I, Yagi Y, Sakata M, Shimazaki J
Department of Ophthalmology, Tokyo Dental College, Japan.
Br J Ophthalmol. 1996 Feb;80(2):144-7. doi: 10.1136/bjo.80.2.144.
Although 1 week of continuous wearing time (CWT) is recommended for extended wear soft contact lenses (EWSCL), there have been few studies concerning the appropriateness of this or other CWTs. The current study was undertaken to examine the effect of various CWTs on the cornea by observing the corneal epithelium.
Specular microscopy was used to evaluate corneal epithelial changes induced by EWSCL in 19 myopic patients (24.0 (SD 6.7) years), divided into four groups: CWT of 0, 1, 3, and 6 days.
The initial mean cell area was 628.2 (13.4) micron2. After 6 months this was 629.3 (28.6) micron2 for daily wear (ns), and 660.0 (40.9) micron2, 727.7 (49.6) micron2 (p < 0.01), and 815.5 (67.2) micron2 (p < 0.01) for CWT of 1, 3, and 6 days, respectively (p < 0.01).
These findings indicate that the corneal epithelium changes proportionally with the CWT; the shorter the CWT, the better the epithelial morphology. This suggests that the CWT for EWSCL be minimised, so as to reduce the potential risk of contact lens related problems.
尽管长戴型软性角膜接触镜（EWSCL）建议连续佩戴时间（CWT）为1周，但关于此时长或其他CWT时长的适宜性研究较少。本研究旨在通过观察角膜上皮来探讨不同CWT对角膜的影响。
采用镜面反射显微镜评估19例近视患者（年龄24.0（标准差6.7）岁）佩戴EWSCL引起的角膜上皮变化，这些患者被分为四组：CWT分别为0天、1天、3天和6天。
初始平均细胞面积为628.2（13.4）平方微米。6个月后，每日佩戴组为629.3（28.6）平方微米（无显著差异），CWT为1天、3天和6天组分别为660.0（40.9）平方微米（p<0.01）、727.7（49.6）平方微米（p<0.01）和815.5（67.2）平方微米（p<0.01）（p<0.01）。
这些发现表明角膜上皮变化与CWT成比例；CWT越短，上皮形态越好。这表明应尽量缩短EWSCL的CWT，以降低与隐形眼镜相关问题的潜在风险。
