新型 4-羟基香豆素亚胺和氨基衍生物的高效合成及抗氧化性能。
An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins.
机构信息
University of Kragujevac, Faculty of Science, Department of Chemistry, Laboratory for Biochemistry, P.O. Box 60, 34000 Kragujevac, Serbia.
出版信息
Arch Pharm Res. 2010 Jan;33(1):5-15. doi: 10.1007/s12272-010-2220-z. Epub 2010 Feb 27.
Series of imino and amino derivatives of 4-hydroxy coumarins were synthesized via conventional and microwave promoted procedure and evaluated for antioxidant potential through different in vitro models such as (DPPH) free radical scavenging activity, linoleic acid emulsion model system, reducing power assay and phosphomolybdenum method. All prepared compounds possess good antioxidant activity and among them p-nitro-phenyl derivative 6c with IC50 at 25.9 microM possesses radical scavenging activity which is comparable to standard BHT, while the best reducing power was observed in a case of benzyl amino compound 8c (RP50 255.6 microM). Also, observed data indicated that compounds may serve as inhibitors of lipid peroxidation process.
通过常规和微波促进程序合成了一系列 4-羟基香豆素的亚氨基和氨基衍生物，并通过不同的体外模型（如 DPPH 自由基清除活性、亚油酸乳液模型系统、还原能力测定和磷钼酸盐法）评估了它们的抗氧化潜力。所有制备的化合物都具有良好的抗氧化活性，其中具有 IC50 为 25.9μM 的自由基清除活性的对硝基苯基衍生物 6c 可与标准 BHT 相媲美，而在苄氨基化合物 8c（RP50 为 255.6μM）的情况下观察到最佳的还原能力。此外，观察到的数据表明，这些化合物可能可作为脂质过氧化过程的抑制剂。
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