呋喃并[2,3-c]吡啶区域选择性锂化反应的工具箱。
Toolbox for regioselective lithiations of furo[2,3-c]pyridine.
机构信息
Groupe Synthèse Organométallique et Réactivité, SRSMC, Nancy-Université, CNRS, B.P. 239, Boulevard des Aiguillettes, F-54506 Vandoeuvre-lès-Nancy, France.
出版信息
J Org Chem. 2010 Apr 2;75(7):2227-35. doi: 10.1021/jo902666w.
PMID:20192243
Abstract
A detailed procedure for successive regioselective lithiations of furo[2,3-c]pyridine is described by using n-BuLi and the [n-BuLi/LiDMAE] superbase. Several polysubstituted furo[2,3-c]pyridines have been efficiently synthesized and some of them were engaged in Pd- or Ni-catalyzed coupling reactions leading to 2,2'- or 7,7'-bifuro[2,3-c]pyridine ligands.
摘要
本文描述了使用正丁基锂和[n-BuLi/LiDMAE]超碱对呋[2,3-c]吡啶进行连续区域选择性锂化的详细过程。通过该方法高效合成了多种多取代的呋[2,3-c]吡啶，其中一些可参与 Pd 或 Ni 催化偶联反应，生成 2,2'-或 7,7'-双呋[2,3-c]吡啶配体。
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