Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Org Lett. 2010 Apr 2;12(7):1420-3. doi: 10.1021/ol902890j.
A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.
合成了一种与荧光丹磺酰基部分缀合的细胞毒性青蒿素衍生物，并研究了其在 Hep3B 细胞中的亚细胞定位。将荧光青蒿素衍生物的定位信号与细胞器特异性染料进行比较，结果表明内质网（ER）是其主要蓄积部位。
